Heres my favorite game Killer 7. Its a complete mind-fuck. If you can get past the weird art style it is an amazing game.
This one of my favorite scenes:
The backstory to this scene is Curtis and Pedro run an orphanage where they kill and harvest the organs of the orphans on the blackmarket. Curtis handles the girls and Pedro the boys. Curtis finds out Pedro is fucking him over and taking some of his children and the scene above is the result...
That's the real shit. I've been wanting to buy a wii just so I can play No More Heroes, which was made by the same bloke Suda51.
He has this game on the DS called Flower, Sun and Rain which is so bizarre in it's vision that it's almost unplayable.
Like, the gameplay and characters can be strange and tedious at the same time but it all seems to be making a point about how people relate to characters they play in videogames. But it comes through gameplay which is basically running from one badly designed puzzle to the next. I only kept playing because in the first puzzle you have to jab a power cord from your briefcase into a truckdriver's eye.
It's such an incredible experience but there's almost nothing fun about playing it whatsoever.