Any reason? I worked in bike shops for a long time and there is no difference in the performance of anything from 105 and nicer that is easily discernible. You're just paying for a few less grams and fancier materials and finish, or maybe an extra cog in the back. If you're racing and shit that's fine and understandable, but if you just ride for fitness or whatever it's kinda opposite to your goal... I put the heaviest and most durable stuff on my commuter bike, more of a workout and eventually it doesn't feel heavy.
If you're set on upgrading anyway, hopefully because your drivetrain is just worn out, I would definitely go Ultegra over Dura-Ace, the second highest tier group is usually pretty good bang for the buck, but the highest tier is always the worst bang for the buck... it will cost literally twice as much and the only thing you get is, idk, a couple hundred grams of weight savings.