I've been on a Home Movies kick after discovering the entire series as one huge ass Youtube video (linked below):
The writing is fantastic, and it's cool to hear H. Jon Benjamin pre-Bob's Burgers. Forgot how funny some of the songs are too.
One of the best shows ever. I think there was supposed to be one more season and ASwim cut it early. Same goes for Venture Bros.
Boondocks is absolutely brilliant as well other than the last season, which was just a bunch of movie spoofs. They were going to start up again on HBO, but after the voice of grandad died and a few other things happened it was shelved :'(
And, I feel like I'm an outlier on this one, but American Dad is often great. Better than Family Guy, Simpsons, or Futurama at this point.