Powell-Peralta and World.
World (and by that I mean, World, 101, Blind, Menace, etc) and its set-up changed the game housing that many interlinked companies through one distrobution and ended the mega-teams of the late 80's. Then you factor in the controversial graphics, Big Brother (and what that spawned), and the people who came through there to eventually start their own brands is unreal. Some of the most revered brands that weren't through World are built by guys who were there. Most notably Girl/Chocolate, and Stereo (A Visual Sound/Tin Can Folklore era).
Honorable mention to Alien, and the aesthetic they created that many have tried to replicate but can't quite capture.